Contraception, Volume 87, Issue 3, March 2013, Pages 280-287
The first-ever efficacy trials on a birth control vaccine established high efficacy (one pregnancy in 1224 cycles) of anti-hCG antibodies at and above 50 ng/mL titers. Fertility was regained in the immediate next cycle, at titers falling below 35 ng/mL.
A recombinant vaccine, hCGβ-LTB, has been made, which is highly immunogenic in mice. It is due to undergo toxicology studies prior to resumption of clinical trials. An additional utility of this vaccine is likely in advanced-stage terminal cancers expressing hCG/subunits.
- 1. Introduction
- 2. Rendering hCG-β immunogenic
- 3. Safety and reversibility
- 4. Enhancement of immunogenicity
- 5. Is partial cross-reaction with hLH problematic?
- 6. Examination of sera for cross-reactive hazardous antibodies from women immunized with hCG- β-TT/DT and hCG-β CTP-DT
- 7. Phase II efficacy trials
- 8. Lack of deleterious side effects on progeny
- 9. Revival of the anti-hCG vaccine
- 10. Ectopic expression of hCG/subunits by cancers
Greetings from Stellenbosch!
For the next 2 weeks our Agenda journal special issue on “The Politics of Women’s Health in South Africa” will be available online for free:
Correspondence about this project is welcomed off-list.
Mandisa Mbali, DPhil (Oxon)
Many WHOM members have encouraged and supported me in this research over many years, so wanted to share the news that some of my research on Verina Morton Jones has finally made it into print! Thanks.
Susan K. Rishworth, MLS, MA, CA
American College of Surgeons
633 N. St. Clair Street
Chicago, IL 60611
I’m now a guest blogger for Ms. online covering women’s health issues, and I thought I’d let interested authors on this list know. If you have a book that came out recently (or one that can be directly tied to present current events), please query me personally about sending me a copy and press materials. As the mother of two sons under 2, my reading time is limited, so I will only have you send me a book if I can promise I can read it.
But this blog does give me a good excuse to carve out time for important books, and maybe plant a seed for others to cover them also. I know as the author myself that it can be challenging to get mainstream media coverage for a feminist health book.
FYI, here are my first two postings, about the meager state of federal-funding for migraine, and its effect on migraine sufferers (mostly women) on a day-to-day level:
PS: I’m also writing one about how GIs coming back from the wars with major migraine problems is spurring new research on the disease. If there are any historians who know about how veterans have influenced research in rehabilitation issues, please email me off list. Thanks!
Dear WHOM Colleagues,
In case you want to add some global dimension to your teaching on women’s healthcare, a wonderful study on Egyptian midwives is available for free access:
Off to Work At Home: Egyptian Midwives Blur Public-Private Boundaries
Author: Abugideiri, Hibba
Source: Hawwa , Volume 6, Number 3, 2008 , pp. 254-283(30)
Also, in case the word isn’t spreading, all issues of Medical History are now available for open access on PubMed Central. (Lots of other medical journals are there, too, and some older ones have valuable medical-historical pieces.)
Professor of History
Arizona State University
Tempe, AZ 85287-4302